A core viral protein binds host nucleosomes to sequester immune danger signals

Viral proteins mimic host protein structure and function to redirect cellular processes and subvert innate defenses(1). Small basic proteins compact and regulate both viral and cellular DNA genomes. Nucleosomes are the repeating units of cellular chromatin and play an important role in innate immune...

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Veröffentlicht in:Nature
Hauptverfasser: Avgousti, Daphne C., Herrmann, Christin, Kulej, Katarzyna, Pancholi, Neha J., Sekulic, Nikolina, Petrescu, Joana, Molden, Rosalynn C., Blumenthal, Daniel, Paris, Andrew J., Reyes, Emigdio D., Ostapchuk, Philomena, Hearing, Patrick, Seeholzer, Steven H., Worthen, G. Scott, Black, Ben E., Garcia, Benjamin A., Weitzman, Matthew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950998/
https://ncbi.nlm.nih.gov/pubmed/27362237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18317
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