Molecular mechanisms autonomic dysfunction and impaired cardiac contractility in critical illness

Objectives: Molecular mechanisms linking autonomic dysfunction with poorer clinical outcomes in critical illness remain unclear. We hypothesized that baroreflex dysfunction alone is sufficient to cause cardiac impairment through neurohormonal activation of (NADPH oxidase-dependent) oxidative stress...

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Detalhes bibliográficos
Publicado no:Crit Care Med
Main Authors: Ackland, Gareth L., Whittle, John, Toner, Andrew, Machhada, Asif, Gutierrez Del Arroyo, Ana, Sciuso, Alberto, Jenkins, Nicholas, Dyson, Alex, Struthers, Richard, Sneyd, Robert, Minto, Gary, Singer, Mervyn, Shah, Ajay M., Gourine, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950969/
https://ncbi.nlm.nih.gov/pubmed/26950003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000001606
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