Targeting the RB-E2F pathway in breast cancer

Mutations of the retinoblastoma tumor suppressor gene (RB1) or components regulating the CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-establishing cell cycle control through CDK inhibition has therefore emerged as an attractive option in the development of targeted ca...

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Publicado en:Oncogene
Main Authors: Johnson, Jackie, Thijssen, Bram, McDermott, Ultan, Garnett, Mathew, Wessels, Lodewyk F.A., Bernards, René
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950965/
https://ncbi.nlm.nih.gov/pubmed/26923330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.32
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