Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis

Ligand efficiency has proven to be a valuable concept for optimization of leads in the early stages of drug design. Taking this one step further, group efficiency (GE) evaluates the binding efficiency of each appendage of a molecule, further fine‐tuning the drug design process. Here, GE analysis is...

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Vydáno v:ChemMedChem
Hlavní autoři: Hung, Alvin W., Silvestre, H. Leonardo, Wen, Shijun, George, Guillaume P. C., Boland, Jennifer, Blundell, Tom L., Ciulli, Alessio, Abell, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949533/
https://ncbi.nlm.nih.gov/pubmed/26486566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500414
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