Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation

OBJECTIVES: No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4 counts > 350 cells/μL. It is hypothesized that earlier initiation of cART in asymptomatic and otherwise healthy individuals may lead to poorer...

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Opis bibliograficzny
Wydane w:HIV Med
Główni autorzy: Jose, S, Quinn, K, Dunn, D, Cox, A, Sabin, C, Fidler, S, Ainsworth, Jonathan, Allan, Sris, Anderson, Jane, Babiker, Abdel, Chadwick, David, Delpech, Valerie, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hay, Phillip, Hill, Teresa, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Martin, Fabiola, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Pritchard, Jillian, Sachikonye, Memory, Schwenk, Achim, Tariq, Anjum, Walsh, John, Thornton, Alicia, Glabay, Adam, Perry, N, Tilbury, S, Youssef, E, Churchill, D, Everett, R, Asboe, D, Mandalia, S, Korat, H, Taylor, C, Gleisner, Z, Ibrahim, F, Campbell, L, Brima, N, Williams, I, Youle, M, Lampe, F, Smith, C, Tsintas, R, Chaloner, C, Hutchinson, S, Huntington, S, Mackie, N, Winston, A, Weber, J, Ramzan, F, Carder, M, Lynch, J, Hand, J, Souza, C, Munshi, S, Miller, S, Wood, C, Wilson, A, Morris, S, Allan, S, Palfreeman, A, Memon, K, ewszuk, A, Chadwick, D, Cope, E, Gibson, J, Kegg, S, Main, P, Mitchell, Dr, Hunter, Dr, Hay, P, Dhillon, M, Martin, F, Russell‐Sharpe, S, Harte, A, Clay, S, Tariq, A, Spencer, H, Jones, R, Atkinson, C, Delpech, V, Sachikonye, M, Aitken, Celia, Pozniak, Anton, Cane, Patricia, Clark, Duncan, Collins, Simon, Douthwaite, Samuel, White, Ellen, Fraser, Christophe, Geretti, Anna Maria, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh‐Brown, Andrew, Mbisa, Tamyo, Moses, Samuel, Nastouli, Eleni, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Webster, Daniel, Zhang, Hongyi, Greatorex, Jane, Mullen, Jane, Tandy, Richard, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia‐Diaz, Ana, Shepherd, Jill, Schmid, Matthias L, Payne, Brendan, Pere, Spiro, Hubb, Jonathan, Kirk, Stuart, Gunson, Rory, Bradley‐Stewart, Amanda
Format: Artigo
Język:Inglês
Wydane: John Wiley and Sons Inc. 2015
Hasła przedmiotowe:
Short Communication
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949527/
https://ncbi.nlm.nih.gov/pubmed/26306942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/hiv.12302
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