Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation

OBJECTIVES: No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4 counts > 350 cells/μL. It is hypothesized that earlier initiation of cART in asymptomatic and otherwise healthy individuals may lead to poorer...

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Bibliografische gegevens
Gepubliceerd in:HIV Med
Hoofdauteurs: Jose, S, Quinn, K, Dunn, D, Cox, A, Sabin, C, Fidler, S, Ainsworth, Jonathan, Allan, Sris, Anderson, Jane, Babiker, Abdel, Chadwick, David, Delpech, Valerie, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hay, Phillip, Hill, Teresa, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Martin, Fabiola, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Pritchard, Jillian, Sachikonye, Memory, Schwenk, Achim, Tariq, Anjum, Walsh, John, Thornton, Alicia, Glabay, Adam, Perry, N, Tilbury, S, Youssef, E, Churchill, D, Everett, R, Asboe, D, Mandalia, S, Korat, H, Taylor, C, Gleisner, Z, Ibrahim, F, Campbell, L, Brima, N, Williams, I, Youle, M, Lampe, F, Smith, C, Tsintas, R, Chaloner, C, Hutchinson, S, Huntington, S, Mackie, N, Winston, A, Weber, J, Ramzan, F, Carder, M, Lynch, J, Hand, J, Souza, C, Munshi, S, Miller, S, Wood, C, Wilson, A, Morris, S, Allan, S, Palfreeman, A, Memon, K, ewszuk, A, Chadwick, D, Cope, E, Gibson, J, Kegg, S, Main, P, Mitchell, Dr, Hunter, Dr, Hay, P, Dhillon, M, Martin, F, Russell‐Sharpe, S, Harte, A, Clay, S, Tariq, A, Spencer, H, Jones, R, Atkinson, C, Delpech, V, Sachikonye, M, Aitken, Celia, Pozniak, Anton, Cane, Patricia, Clark, Duncan, Collins, Simon, Douthwaite, Samuel, White, Ellen, Fraser, Christophe, Geretti, Anna Maria, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh‐Brown, Andrew, Mbisa, Tamyo, Moses, Samuel, Nastouli, Eleni, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Webster, Daniel, Zhang, Hongyi, Greatorex, Jane, Mullen, Jane, Tandy, Richard, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia‐Diaz, Ana, Shepherd, Jill, Schmid, Matthias L, Payne, Brendan, Pere, Spiro, Hubb, Jonathan, Kirk, Stuart, Gunson, Rory, Bradley‐Stewart, Amanda
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2015
Onderwerpen:
Short Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949527/
https://ncbi.nlm.nih.gov/pubmed/26306942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/hiv.12302
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