Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation

OBJECTIVES: No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4 counts > 350 cells/μL. It is hypothesized that earlier initiation of cART in asymptomatic and otherwise healthy individuals may lead to poorer...

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izdano v:HIV Med
Main Authors: Jose, S, Quinn, K, Dunn, D, Cox, A, Sabin, C, Fidler, S, Ainsworth, Jonathan, Allan, Sris, Anderson, Jane, Babiker, Abdel, Chadwick, David, Delpech, Valerie, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hay, Phillip, Hill, Teresa, Johnson, Margaret, Kegg, Stephen, Leen, Clifford, Martin, Fabiola, Nelson, Mark, Orkin, Chloe, Palfreeman, Adrian, Phillips, Andrew, Pillay, Deenan, Post, Frank, Pritchard, Jillian, Sachikonye, Memory, Schwenk, Achim, Tariq, Anjum, Walsh, John, Thornton, Alicia, Glabay, Adam, Perry, N, Tilbury, S, Youssef, E, Churchill, D, Everett, R, Asboe, D, Mandalia, S, Korat, H, Taylor, C, Gleisner, Z, Ibrahim, F, Campbell, L, Brima, N, Williams, I, Youle, M, Lampe, F, Smith, C, Tsintas, R, Chaloner, C, Hutchinson, S, Huntington, S, Mackie, N, Winston, A, Weber, J, Ramzan, F, Carder, M, Lynch, J, Hand, J, Souza, C, Munshi, S, Miller, S, Wood, C, Wilson, A, Morris, S, Allan, S, Palfreeman, A, Memon, K, ewszuk, A, Chadwick, D, Cope, E, Gibson, J, Kegg, S, Main, P, Mitchell, Dr, Hunter, Dr, Hay, P, Dhillon, M, Martin, F, Russell‐Sharpe, S, Harte, A, Clay, S, Tariq, A, Spencer, H, Jones, R, Atkinson, C, Delpech, V, Sachikonye, M, Aitken, Celia, Pozniak, Anton, Cane, Patricia, Clark, Duncan, Collins, Simon, Douthwaite, Samuel, White, Ellen, Fraser, Christophe, Geretti, Anna Maria, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh‐Brown, Andrew, Mbisa, Tamyo, Moses, Samuel, Nastouli, Eleni, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Webster, Daniel, Zhang, Hongyi, Greatorex, Jane, Mullen, Jane, Tandy, Richard, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia‐Diaz, Ana, Shepherd, Jill, Schmid, Matthias L, Payne, Brendan, Pere, Spiro, Hubb, Jonathan, Kirk, Stuart, Gunson, Rory, Bradley‐Stewart, Amanda
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Short Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949527/
https://ncbi.nlm.nih.gov/pubmed/26306942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/hiv.12302
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