A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance

Epidemiological and experimental data implicate branched chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms underlying this link remain unclear.(1–3) Insulin resistance in skeletal muscle stems from excess accumulation of lipid species(4), a process that requires...

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Publicado no:Nat Med
Main Authors: Jang, Cholsoon, Oh, Sungwhan F, Wada, Shogo, Rowe, Glenn C, Liu, Laura, Chan, Mun Chun, Rhee, James, Hoshino, Atsushi, Kim, Boa, Ibrahim, Ayon, Baca, Luisa G, Kim, Esl, Ghosh, Chandra C, Parikh, Samir M, Jiang, Aihua, Chu, Qingwei, Forman, Daniel E., Lecker, Stewart H., Krishnaiah, Saikumari, Rabinowitz, Joshua D, Weljie, Aalim M, Baur, Joseph A, Kasper, Dennis L, Arany, Zoltan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949205/
https://ncbi.nlm.nih.gov/pubmed/26950361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4057
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