Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy

OBJECTIVE: Hepatic ischemia-reperfusion (I/R) is a major clinical problem with limited treatment options. The pathophysiology of hepatic I/R is characterized by mitochondrial dysfunction and cellular energy deficits. Sirtuin 1 (Sirt1) is an energy-sensing enzyme known to modulate mitochondrial bioge...

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Detaylı Bibliyografya
Yayımlandı:Crit Care Med
Asıl Yazarlar: Khader, Adam, Yang, Weng-Lang, Godwin, Andrew, Prince, Jose M, Nicastro, Jeffrey M, Coppa, Gene F, Wang, Ping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949129/
https://ncbi.nlm.nih.gov/pubmed/26963320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000001637
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