Inhibition of Advanced Glycation End Products (AGEs) Accumulation by Pyridoxamine Modulates Glomerular and Mesangial Cell Estrogen Receptor α Expression in Aged Female Mice

Age-related increases in oxidant stress (OS) play a role in regulation of estrogen receptor (ER) expression in the kidneys. In this study, we establish that in vivo 17β-estradiol (E(2)) replacement can no longer upregulate glomerular ER expression by 21 months of age in female mice (anestrous). We h...

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Publicado en:PLoS One
Autores principales: Pereira-Simon, Simone, Rubio, Gustavo A., Xia, Xiaomei, Cai, Weijing, Choi, Rhea, Striker, Gary E., Elliot, Sharon J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948910/
https://ncbi.nlm.nih.gov/pubmed/27428057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159666
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