Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing T(H)17 cells and preserving ILC3

RAR-related orphan receptor γt (ROR-γt) directs differentiation of pro-inflammatory T helper 17 (T(H)17) cells and is a potential therapeutic target in chronic autoimmune and inflammatory diseases(1–3). However, ROR-γt-dependent group 3 innate lymphoid cells (ILC3s) provide essential immunity and ti...

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Gepubliceerd in:Nat Med
Hoofdauteurs: Withers, David R., Hepworth, Matthew R., Wang, Xinxin, Mackley, Emma C., Halford, Emily E., Dutton, Emma E., Marriott, Clare L., Brucklacher-Waldert, Verena, Veldhoen, Marc, Kelsen, Judith, Baldassano, Robert N., Sonnenberg, Gregory F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948756/
https://ncbi.nlm.nih.gov/pubmed/26878233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4046
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