Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair

NEIL1 (Nei-like 1) is a DNA repair glycosylase guarding the mammalian genome against oxidized DNA bases. As the first enzymes in the base-excision repair pathway, glycosylases must recognize the cognate substrates and catalyze their excision. Here we present crystal structures of human NEIL1 bound t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhu, Chenxu, Lu, Lining, Zhang, Jun, Yue, Zongwei, Song, Jinghui, Zong, Shuai, Liu, Menghao, Stovicek, Olivia, Gao, Yi Qin, Yi, Chengqi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948311/
https://ncbi.nlm.nih.gov/pubmed/27354518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604591113
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