Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma

BACKGROUND: BRAF(V600E)-mediated MAPK pathway activation is associated in melanoma cells with IFNAR1 downregulation. IFNAR1 regulates melanoma cell sensitivity to IFNα, a cytokine used for the adjuvant treatment of melanoma. These findings and the limited therapeutic efficacy of BRAF-I prompted us t...

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Publicado en:J Natl Cancer Inst
Autores principales: Sabbatino, Francesco, Wang, Yangyang, Scognamiglio, Giosuè, Favoino, Elvira, Feldman, Steven A., Villani, Vincenzo, Flaherty, Keith T., Nota, Sjoerd, Giannarelli, Diana, Simeone, Ester, Anniciello, Anna M., Palmieri, Giuseppe, Pepe, Stefano, Botti, Gerardo, Ascierto, Paolo A., Ferrone, Cristina R., Ferrone, Soldano
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948304/
https://ncbi.nlm.nih.gov/pubmed/26851802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv435
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