A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon (VEMUPLINT) in advanced melanoma patients harboring the V600BRAF mutation

BACKGROUND: Studies carried out in vitro and in a mouse model have shown that BRAF inhibitors enhance the effects of IFN-α on BRAFV600E melanoma cells through the inhibition of ERK. Therefore, the combination of vemurafenib and IFN-α in patients with BRAFV600E melanoma may provide therapeutic benefi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Simeone, Ester, Scognamiglio, Giosuè, Capone, Mariaelena, Giannarelli, Diana, Grimaldi, Antonio M., Mallardo, Domenico, Madonna, Gabriele, Curvietto, Marcello, Esposito, Assunta, Sandomenico, Fabio, Sabbatino, Francesco, Bayless, Nicholas L., Warren, Sarah, Ong, SuFey, Botti, Gerardo, Flaherty, Keith T., Ferrone, Soldano, Ascierto, Paolo A.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789377/
https://ncbi.nlm.nih.gov/pubmed/33407577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02680-7
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker