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A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon (VEMUPLINT) in advanced melanoma patients harboring the V600BRAF mutation

BACKGROUND: Studies carried out in vitro and in a mouse model have shown that BRAF inhibitors enhance the effects of IFN-α on BRAFV600E melanoma cells through the inhibition of ERK. Therefore, the combination of vemurafenib and IFN-α in patients with BRAFV600E melanoma may provide therapeutic benefi...

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Библиографические подробности
Опубликовано в: :J Transl Med
Главные авторы: Simeone, Ester, Scognamiglio, Giosuè, Capone, Mariaelena, Giannarelli, Diana, Grimaldi, Antonio M., Mallardo, Domenico, Madonna, Gabriele, Curvietto, Marcello, Esposito, Assunta, Sandomenico, Fabio, Sabbatino, Francesco, Bayless, Nicholas L., Warren, Sarah, Ong, SuFey, Botti, Gerardo, Flaherty, Keith T., Ferrone, Soldano, Ascierto, Paolo A.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789377/
https://ncbi.nlm.nih.gov/pubmed/33407577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02680-7
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