Inhibition of Poly(ADP-Ribose) Polymerase by Nucleic Acid Metabolite 7-Methylguanine

The ability of 7-methylguanine, a nucleic acid metabolite, to inhibit poly(ADP-ribose)polymerase-1 (PARP-1) and poly(ADP-ribose)polymerase-2 (PARP-2) has been identified in silico and studied experimentally. The amino group at position 2 and the methyl group at position 7 were shown to be important...

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Udgivet i:Acta Naturae
Main Authors: Nilov, D. K., Tararov, V. I., Kulikov, A. V., Zakharenko, A. L., Gushchina, I. V., Mikhailov, S. N., Lavrik, O. I., Švedas, V. K.
Format: Artigo
Sprog:Inglês
Udgivet: A.I. Gordeyev 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947994/
https://ncbi.nlm.nih.gov/pubmed/27437145
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