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Spatial Moran models, II: cancer initiation in spatially structured tissue

We study the accumulation and spread of advantageous mutations in a spatial stochastic model of cancer initiation on a lattice. The parameters of this general model can be tuned to study a variety of cancer types and genetic progression pathways. This investigation contributes to an understanding of...

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Pubblicato in:J Math Biol
Autori principali: Durrett, R, Foo, J, Leder, K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947874/
https://ncbi.nlm.nih.gov/pubmed/26126947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00285-015-0912-1
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