Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation

PURPOSE: We employed a metabolomics-based approach with the goal to better understand the molecular signatures of glioblastoma (GBM) cells and tissues, with an aim towards identifying potential targetable biomarkers for developing more effective and novel therapies. EXPERIMENTAL DESIGN: We used liqu...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Palanichamy, Kamalakannan, Thirumoorthy, Krishnan, Kanji, Suman, Gordon, Nicolaus, Singh, Rajbir, Jacob, John R, Sebastian, Nikhil, Litzenberg, Kevin T, Patel, Disha, Bassett, Emily, Ramasubramanian, Brinda, Lautenschlaeger, Tim, Fischer, Steven M, Ray-Chaudhury, Abhik, Chakravarti, Arnab
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947420/
https://ncbi.nlm.nih.gov/pubmed/26936918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2308
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