Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation

PURPOSE: We employed a metabolomics-based approach with the goal to better understand the molecular signatures of glioblastoma (GBM) cells and tissues, with an aim towards identifying potential targetable biomarkers for developing more effective and novel therapies. EXPERIMENTAL DESIGN: We used liqu...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Palanichamy, Kamalakannan, Thirumoorthy, Krishnan, Kanji, Suman, Gordon, Nicolaus, Singh, Rajbir, Jacob, John R, Sebastian, Nikhil, Litzenberg, Kevin T, Patel, Disha, Bassett, Emily, Ramasubramanian, Brinda, Lautenschlaeger, Tim, Fischer, Steven M, Ray-Chaudhury, Abhik, Chakravarti, Arnab
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947420/
https://ncbi.nlm.nih.gov/pubmed/26936918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2308
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