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Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation

PURPOSE: We employed a metabolomics-based approach with the goal to better understand the molecular signatures of glioblastoma (GBM) cells and tissues, with an aim towards identifying potential targetable biomarkers for developing more effective and novel therapies. EXPERIMENTAL DESIGN: We used liqu...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Palanichamy, Kamalakannan, Thirumoorthy, Krishnan, Kanji, Suman, Gordon, Nicolaus, Singh, Rajbir, Jacob, John R, Sebastian, Nikhil, Litzenberg, Kevin T, Patel, Disha, Bassett, Emily, Ramasubramanian, Brinda, Lautenschlaeger, Tim, Fischer, Steven M, Ray-Chaudhury, Abhik, Chakravarti, Arnab
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947420/
https://ncbi.nlm.nih.gov/pubmed/26936918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2308
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