Toremifene interacts with and destabilizes the Ebola virus glycoprotein

Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including the recent deadly epidemic in West Africa. There are currently no approved therapeutic drugs or vaccines for the disease. EBOV has a membrane envelope decorated by trimers of a glycoprotein (GP, cleaved by fu...

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Veröffentlicht in:Nature
Hauptverfasser: Zhao, Yuguang, Ren, Jingshan, Harlos, Karl, Jones, Daniel M., Zeltina, Antra, Bowden, Thomas A., Padilla-Parra, Sergi, Fry, Elizabeth E., Stuart, David I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947387/
https://ncbi.nlm.nih.gov/pubmed/27362232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18615
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