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Deleting both PHLPP1 and CANP1 rescues impairments in long-term potentiation and learning in both single knockout mice
Calpain-1 (CANP1) has been shown to play a critical role in synaptic plasticity and learning and memory, as its deletion in mice results in impairment in theta-burst stimulation- (TBS) induced LTP and various forms of learning and memory. Likewise, PHLPP1 (aka SCOP) has also been found to participat...
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| Publicado no: | Learn Mem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4947237/ https://ncbi.nlm.nih.gov/pubmed/27421891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.042721.116 |
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