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SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
SREBP1c is a key lipogenic transcription factor activated by insulin in the postprandial state. Although SREBP1c appears to be involved in suppression of hepatic gluconeogenesis, the molecular mechanism is not thoroughly understood. Here we show that CRY1 is activated by insulin-induced SREBP1c and...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4947181/ https://ncbi.nlm.nih.gov/pubmed/27412556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12180 |
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