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Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition
The enzyme ribonucleotide reductase (RNR) is a major target of anticancer drugs. Until recently, suicide inactivation in which synthetic substrate analogs (nucleoside diphosphates) irreversibly inactivate the RNR-α(2)β(2) heterodimeric complex was the only clinically proven inhibition pathway. For i...
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| 出版年: | ACS Chem Biol |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4946967/ https://ncbi.nlm.nih.gov/pubmed/27159113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00303 |
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