Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation

Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent homologous recombination, which is thought to require locus-specific initiation. Here, we show that a RecQ helicase, RECQ2, acts to...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Devlin, Rebecca, Marques, Catarina A, Paape, Daniel, Prorocic, Marko, Zurita-Leal, Andrea C, Campbell, Samantha J, Lapsley, Craig, Dickens, Nicholas, McCulloch, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2016
Schlagworte:
Genes and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946898/
https://ncbi.nlm.nih.gov/pubmed/27228154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12765
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