Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

Interleukin-1β (IL-1β) is a critical regulator of the inflammatory response. IL-1β is not secreted through the conventional ER–Golgi route of protein secretion, and to date its mechanism of release has been unknown. Crucially, its secretion depends upon the processing of a precursor form following t...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Martín-Sánchez, F, Diamond, C, Zeitler, M, Gomez, A I, Baroja-Mazo, A, Bagnall, J, Spiller, D, White, M, Daniels, M J D, Mortellaro, A, Peñalver, M, Paszek, P, Steringer, J P, Nickel, W, Brough, D, Pelegrín, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946890/
https://ncbi.nlm.nih.gov/pubmed/26868913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.176
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