Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3(L423P) Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle

During nephrogenesis, POU domain class 3 transcription factor 3 (POU3F3 aka BRN1) is critically involved in development of distinct nephron segments, including the thick ascending limb of the loop of Henle (TAL). Deficiency of POU3F3 in knock-out mice leads to underdevelopment of the TAL, lack of di...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rieger, Alexandra, Kemter, Elisabeth, Kumar, Sudhir, Popper, Bastian, Aigner, Bernhard, Wolf, Eckhard, Wanke, Rüdiger, Blutke, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946790/
https://ncbi.nlm.nih.gov/pubmed/27420727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158977
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