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Two-photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement

Small molecule therapeutic drugs must reach their intended cellular targets (pharmacokinetics) and engage them to modulate therapeutic effects (pharmacodynamics). These processes are often difficult to measure in vivo due to their complexities and occurrence within single cells. It has been particul...

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Dades bibliogràfiques
Publicat a:IEEE J Sel Top Quantum Electron
Autors principals: Vinegoni, Claudio, Dubach, John M., Feruglio, Paolo Fumene, Weissleder, Ralph
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946648/
https://ncbi.nlm.nih.gov/pubmed/27440991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/JSTQE.2015.2501384
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