Interferon-α signaling promotes embryonic HSC maturation

In the developing mouse embryo, the first hematopoietic stem cells (HSCs) arise in the aorta-gonad-mesonephros (AGM) and mature as they transit through the fetal liver (FL). Compared with FL and adult HSCs, AGM HSCs have reduced repopulation potential in irradiated adult transplant recipients but me...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Kim, Peter Geon, Canver, Matthew C., Rhee, Catherine, Ross, Samantha J., Harriss, June V., Tu, Ho-Chou, Orkin, Stuart H., Tucker, Haley O., Daley, George Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946201/
https://ncbi.nlm.nih.gov/pubmed/27095787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-689281
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