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TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms
Phosphodiesterase 10A (PDE10A) inhibitors are expected to be novel drugs for schizophrenia through activation of both direct and indirect pathway medium spiny neurons. However, excess activation of the direct pathway by a dopamine D(1) receptor agonist SKF82958 canceled antipsychotic-like effects of...
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Veröffentlicht in: | Neuropsychopharmacology |
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Hauptverfasser: | , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
Nature Publishing Group
2016
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4946053/ https://ncbi.nlm.nih.gov/pubmed/26849714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.20 |
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