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TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms

Phosphodiesterase 10A (PDE10A) inhibitors are expected to be novel drugs for schizophrenia through activation of both direct and indirect pathway medium spiny neurons. However, excess activation of the direct pathway by a dopamine D(1) receptor agonist SKF82958 canceled antipsychotic-like effects of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuropsychopharmacology
Hauptverfasser: Suzuki, Kazunori, Harada, Akina, Suzuki, Hirobumi, Miyamoto, Maki, Kimura, Haruhide
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946053/
https://ncbi.nlm.nih.gov/pubmed/26849714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.20
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