Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor

Phosphodiesterase 10A (PDE10A) inhibition is a novel and promising approach for the treatment of central nervous system disorders such as schizophrenia and Huntington’s disease. A novel PDE10A inhibitor, TAK-063 [1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-pyridazin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Harada, Akina, Suzuki, Kazunori, Kamiguchi, Naomi, Miyamoto, Maki, Tohyama, Kimio, Nakashima, Kosuke, Taniguchi, Takahiko, Kimura, Haruhide
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376699/
https://ncbi.nlm.nih.gov/pubmed/25815469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122197
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