Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models

Cardiovascular complications are the leading cause of death in autosomal dominant polycystic kidney disease (ADPKD), and intracranial aneurysm (ICA) causing subarachnoid hemorrhage is among the most serious complications. The diagnostic and therapeutic strategies for ICAs in ADPKD have not been full...

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Publicado no:Sci Rep
Main Authors: Ameku, Tomonaga, Taura, Daisuke, Sone, Masakatsu, Numata, Tomohiro, Nakamura, Masahiro, Shiota, Fumihiko, Toyoda, Taro, Matsui, Satoshi, Araoka, Toshikazu, Yasuno, Tetsuhiko, Mae, Shin-Ichi, Kobayashi, Hatasu, Kondo, Naoya, Kitaoka, Fumiyo, Amano, Naoki, Arai, Sayaka, Ichisaka, Tomoko, Matsuura, Norio, Inoue, Sumiko, Yamamoto, Takuya, Takahashi, Kazutoshi, Asaka, Isao, Yamada, Yasuhiro, Ubara, Yoshifumi, Muso, Eri, Fukatsu, Atsushi, Watanabe, Akira, Sato, Yasunori, Nakahata, Tatsutoshi, Mori, Yasuo, Koizumi, Akio, Nakao, Kazuwa, Yamanaka, Shinya, Osafune, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945931/
https://ncbi.nlm.nih.gov/pubmed/27418197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30013
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