Epigenetic perturbations by Arg882-mutated DNMT3A potentiate aberrant stem cell gene expression program and acute leukemia development

DNA methyltransferase 3A (DNMT3A) is frequently mutated in hematological cancers; however, the underlying oncogenic mechanism remains elusive. Here, we report that DNMT3A mutational hotspot at Arg882 (DNMT3A(R882H)) cooperates with NRAS mutation to transform hematopoietic stem/progenitor cells and i...

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Udgivet i:Cancer Cell
Main Authors: Lu, Rui, Wang, Ping, Parton, Trevor, Zhou, Yang, Chrysovergis, Kaliopi, Rockowitz, Shira, Chen, Wei-Yi, Abdel-Wahab, Omar, Wade, Paul A., Zheng, Deyou, Wang, Gang Greg
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945461/
https://ncbi.nlm.nih.gov/pubmed/27344947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.05.008
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