Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells

Oncogene-induced DNA methylation-mediated transcriptional silencing of tumor suppressors frequently occurs in cancer, but the mechanism and functional role of this silencing in oncogenesis is not fully understood. Here, we show that oncogenic epidermal growth factor receptor (EGFR) induces silencing...

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Publicado en:Cell Rep
Autores principales: Forloni, Matteo, Gupta, Romi, Nagarajan, Arvindhan, Sun, Li-Sha, Dong, Yuying, Pirazzoli, Valentina, Toki, Maria, Wurtz, Anna, Melnick, Mary Ann, Kobayashi, Susumu, Homer, Robert J., Rimm, David L., Gettinger, Scott J., Politi, Katerina, Dogra, Shaillay Kumar, Wajapeyee, Narendra
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945411/
https://ncbi.nlm.nih.gov/pubmed/27346347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.087
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