Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection

The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 T cell inhibitory molecules are up-regulated in HIV-1 infection and associate with immune dysfunction. We evaluated participants (n = 122) recruited to the SPARTAC randomised clinica...

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Vydáno v:PLoS Pathog
Hlavní autoři: Hoffmann, Matthias, Pantazis, Nikos, Martin, Genevieve E., Hickling, Stephen, Hurst, Jacob, Meyerowitz, Jodi, Willberg, Christian B., Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Babiker, Abdel, Weber, Jonathan, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Phillips, Rodney, Frater, John
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945085/
https://ncbi.nlm.nih.gov/pubmed/27415828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005661
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