Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection

The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 T cell inhibitory molecules are up-regulated in HIV-1 infection and associate with immune dysfunction. We evaluated participants (n = 122) recruited to the SPARTAC randomised clinica...

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Publicado en:PLoS Pathog
Main Authors: Hoffmann, Matthias, Pantazis, Nikos, Martin, Genevieve E., Hickling, Stephen, Hurst, Jacob, Meyerowitz, Jodi, Willberg, Christian B., Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Babiker, Abdel, Weber, Jonathan, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Phillips, Rodney, Frater, John
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945085/
https://ncbi.nlm.nih.gov/pubmed/27415828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005661
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