Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome

Secreted factors of Staphylococcus aureus can activate host signaling from the epidermal growth factor receptor (EGFR). The superantigen toxic shock syndrome toxin-1 (TSST-1) contributes to mucosal cytokine production through a disintegrin and metalloproteinase (ADAM)-mediated shedding of EGFR ligan...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Breshears, Laura M., Gillman, Aaron N., Stach, Christopher S., Schlievert, Patrick M., Peterson, Marnie L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944920/
https://ncbi.nlm.nih.gov/pubmed/27414801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158969
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