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Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome

Secreted factors of Staphylococcus aureus can activate host signaling from the epidermal growth factor receptor (EGFR). The superantigen toxic shock syndrome toxin-1 (TSST-1) contributes to mucosal cytokine production through a disintegrin and metalloproteinase (ADAM)-mediated shedding of EGFR ligan...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Breshears, Laura M., Gillman, Aaron N., Stach, Christopher S., Schlievert, Patrick M., Peterson, Marnie L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944920/
https://ncbi.nlm.nih.gov/pubmed/27414801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158969
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