HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites

The host cell restriction factor CD317/tetherin traps virions at the surface of producer cells to prevent their release. The HIV-1 accessory protein Vpu antagonizes this restriction. Vpu reduces the cell surface density of the restriction factor and targets it for degradation; however, these activit...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Pujol, François M., Laketa, Vibor, Schmidt, Florian, Mukenhirn, Markus, Müller, Barbara, Boulant, Steeve, Grimm, Dirk, Keppler, Oliver T., Fackler, Oliver T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944280/
https://ncbi.nlm.nih.gov/pubmed/27170757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00504-16
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