Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses

Glucocorticoids (GCs) are the standard therapy for treating multiple sclerosis (MS) patients suffering from an acute relapse. One of the main mechanisms of gC action is held to be the induction of T cell apoptosis leading to reduced lymphocyte infiltration into the CNS, yet our analysis of experimen...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Schweingruber, Nils, Fischer, Henrike J., Fischer, Lisa, van den Brandt, Jens, Karabinskaya, Anna, Labi, Verena, Villunger, Andreas, Kretzschmar, Benedikt, Huppke, Peter, Simons, Mikael, Tuckermann, Jan P., Flügel, Alexander, Lühder, Fred, Reichardt, Holger M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943522/
https://ncbi.nlm.nih.gov/pubmed/24488308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1248-4
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