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A Theoretical Lower Bound for Selection on the Expression Levels of Proteins
We use simple models of the costs and benefits of microbial gene expression to show that changing a protein’s expression away from its optimum by 2-fold should reduce fitness by at least [Formula: see text] , where P is the fraction the cell’s protein that the gene accounts for. As microbial genes a...
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| Publicado no: | Genome Biol Evol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4943197/ https://ncbi.nlm.nih.gov/pubmed/27289091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evw126 |
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