Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro

Aminoglycosides are ototoxic to the cochlear hair cells, and mitochondrial dysfunction is one of the major mechanisms behind ototoxic drug-induced hair cell death. TRMU (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase) is a mitochondrial protein that participates in mitochondrial tRNA mod...

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Vydáno v:Sci Rep
Hlavní autoři: He, Zuhong, Sun, Shan, Waqas, Muhammad, Zhang, Xiaoli, Qian, Fuping, Cheng, Cheng, Zhang, Mingshu, Zhang, Shasha, Wang, Yongming, Tang, Mingliang, Li, Huawei, Chai, Renjie
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942793/
https://ncbi.nlm.nih.gov/pubmed/27405449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29621
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