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A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds
Members of arachnida, such as spiders and scorpions, commonly produce venom with specialized venom glands, paralyzing their prey with neurotoxins that specifically target ion channels. Two well-studied motifs, the disulfide-directed hairpin (DDH) and the inhibitor cystine knot motif (ICK), are both...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4942781/ https://ncbi.nlm.nih.gov/pubmed/27407029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29691 |
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