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An Efficient Strategy to Enhance Binding Affinity and Specificity of a Known Isozyme Inhibitor
The binding profile of a known inhibitor, benzensulfonamide, against a family of carbonic anhydrase isozymes was efficiently enhanced via high-throughput screening of customized combinatorial one-bead-one-compound peptide libraries modified with the inhibitor molecule. The screening of the conjugate...
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| Опубликовано в: : | Org Biomol Chem |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4942345/ https://ncbi.nlm.nih.gov/pubmed/27339902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob01104g |
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