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An Efficient Strategy to Enhance Binding Affinity and Specificity of a Known Isozyme Inhibitor
The binding profile of a known inhibitor, benzensulfonamide, against a family of carbonic anhydrase isozymes was efficiently enhanced via high-throughput screening of customized combinatorial one-bead-one-compound peptide libraries modified with the inhibitor molecule. The screening of the conjugate...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4942345/ https://ncbi.nlm.nih.gov/pubmed/27339902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob01104g |
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