Aggregation of Trp > Glu point mutants of human gamma‐D crystallin provides a model for hereditary or UV‐induced cataract

Numerous mutations and covalent modifications of the highly abundant, long‐lived crystallins of the eye lens cause their aggregation leading to progressive opacification of the lens, cataract. The nature and biochemical mechanisms of the aggregation process are poorly understood, as neither amyloid...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Serebryany, Eugene, Takata, Takumi, Erickson, Erika, Schafheimer, Nathaniel, Wang, Yongting, King, Jonathan A.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941774/
https://ncbi.nlm.nih.gov/pubmed/26991007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2924
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