The impact of crystallization conditions on structure‐based drug design: A case study on the methylene blue/acetylcholinesterase complex

Structure‐based drug design utilizes apoprotein or complex structures retrieved from the PDB. >57% of crystallographic PDB entries were obtained with polyethylene glycols (PEGs) as precipitant and/or as cryoprotectant, but <6% of these report presence of individual ethyleneglycol oligomers. We...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Protein Sci
Egile Nagusiak: Dym, Orly, Song, Wanling, Felder, Clifford, Roth, Esther, Shnyrov, Valery, Ashani, Yacov, Xu, Yechun, Joosten, Robbie P., Weiner, Lev, Sussman, Joel L., Silman, Israel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2016
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941771/
https://ncbi.nlm.nih.gov/pubmed/26990888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2923
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