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Host Double Strand Break Repair Generates HIV-1 Strains Resistant to CRISPR/Cas9
CRISPR/Cas9 genome editing has been proposed as a therapeutic treatment for HIV-1 infection. CRISPR/Cas9 induced double strand breaks (DSBs) targeted to the integrated viral genome have been shown to decrease production of progeny virus. Unfortunately HIV-1 evolves rapidly and may readily produce CR...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4941621/ https://ncbi.nlm.nih.gov/pubmed/27404981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29530 |
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