Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection

Antiretroviral therapy-naive HIV-1 infected infants experience poor viral containment and rapid disease progression compared to adults. Viral factors (e.g. transmitted cytotoxic T- lymphocyte (CTL) escape mutations) or infant factors (e.g. reduced CTL functional capacity) may explain this observatio...

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Publicado no:Sci Rep
Main Authors: Garcia-Knight, Miguel A., Slyker, Jennifer, Payne, Barbara Lohman, Pond, Sergei L. Kosakovsky, de Silva, Thushan I., Chohan, Bhavna, Khasimwa, Brian, Mbori-Ngacha, Dorothy, John-Stewart, Grace, Rowland-Jones, Sarah L., Esbjörnsson, Joakim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941567/
https://ncbi.nlm.nih.gov/pubmed/27403940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29536
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