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Evolution of domain–peptide interactions to coadapt specificity and affinity to functional diversity

Evolution of complexity in eukaryotic proteomes has arisen, in part, through emergence of modular independently folded domains mediating protein interactions via binding to short linear peptides in proteins. Over 30 years, structural properties and sequence preferences of these peptides have been ex...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kelil, Abdellali, Levy, Emmanuel D., Michnick, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941456/
https://ncbi.nlm.nih.gov/pubmed/27317745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518469113
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