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Evolution of domain–peptide interactions to coadapt specificity and affinity to functional diversity

Evolution of complexity in eukaryotic proteomes has arisen, in part, through emergence of modular independently folded domains mediating protein interactions via binding to short linear peptides in proteins. Over 30 years, structural properties and sequence preferences of these peptides have been ex...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Kelil, Abdellali, Levy, Emmanuel D., Michnick, Stephen W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941456/
https://ncbi.nlm.nih.gov/pubmed/27317745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518469113
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