Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome

The ribosome is one of the major targets for therapeutic antibiotics; however, the rise in multidrug resistance is a growing threat to the utility of our current arsenal. The orthosomycin antibiotics evernimicin (EVN) and avilamycin (AVI) target the ribosome and do not display cross-resistance with...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Arenz, Stefan, Juette, Manuel F., Graf, Michael, Nguyen, Fabian, Huter, Paul, Polikanov, Yury S., Blanchard, Scott C., Wilson, Daniel N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941455/
https://ncbi.nlm.nih.gov/pubmed/27330110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604790113
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