SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

Glioblastoma multiforme (GBM) is the most aggressive CNS tumor and is characterized by a very high frequency of clinical relapse after therapy and thus by a dismal prognosis, which strongly compromises patients survival. We have recently identified the small molecule SI113, as a potent and selective...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Talarico, Cristina, Dattilo, Vincenzo, D'Antona, Lucia, Barone, Agnese, Amodio, Nicola, Belviso, Stefania, Musumeci, Francesca, Abbruzzese, Claudia, Bianco, Cataldo, Trapasso, Francesco, Schenone, Silvia, Alcaro, Stefano, Ortuso, Francesco, Florio, Tullio, Paggi, Marco G., Perrotti, Nicola, Amato, Rosario
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941283/
https://ncbi.nlm.nih.gov/pubmed/26908461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7520
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