Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy

The SGK1 kinase is pivotal in signal transduction pathways operating in cell transformation and tumor progression. Here, we characterize in depth a novel potent and selective pyrazolo[3,4-d]pyrimidine-based SGK1 inhibitor. This compound, named SI113, active in vitro in the sub-micromolar range, inhi...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Talarico, Cristina, D'Antona, Lucia, Scumaci, Domenica, Barone, Agnese, Gigliotti, Francesco, Vincenza Fiumara, Claudia, Dattilo, Vincenzo, Gallo, Enzo, Visca, Paolo, Ortuso, Francesco, Abbruzzese, Claudia, Botta, Lorenzo, Schenone, Silvia, Cuda, Giovanni, Alcaro, Stefano, Bianco, Cataldo, Lavia, Patrizia, Paggi, Marco G., Perrotti, Nicola, Amato, Rosario
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2015
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741945/
https://ncbi.nlm.nih.gov/pubmed/26462020
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